Identification of the most promising new markets, customer segments, and product and service offerings is critical to sustained profitable growth. The Opportunity-Fit Methodology described in this paper provides a convenient way for business-to-business corporations to compare and select from among the numerous and widely-diverse growth options that are candidates for investment funding. This methodology allows for comparisons among options that involve new geographic markets, new products and services, and new customer segments, in various combinations. The paper also describes how careful attention paid to the customer chains involved in the business-to-business markets under consideration can help to ensure that the maximum benefits are realized from the application of this methodology.